DSIP 5MG

DSIP 5MG

$51.00

DSIP influences endocrine processes within the central nervous system. It’s being studied for reducing oxidative stress and as a potential treatment for depression.

41 in stock (can be backordered)

Quantity Discount / Amount Price
3 4% $48.96
5 9% $46.41
10 12% $44.88
Summary
DSIP 5MG$51.00
$51.00

Product Usage: This product is designated as a "Novelty Peptide" and is intended solely for specialized applications in controlled settings. It is not intended for any specific biological, therapeutic, or diagnostic use. All information provided on this website is for informational and educational purposes only and should not be construed as guidance for any particular application or usage.

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Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring neuropeptide first isolated from the cerebral venous blood of rabbits in 1977 by the Schoenenberger-Monnier group from Basel. Initially thought to be a sleep-promoting factor, DSIP is now recognized as a multifunctional regulatory peptide with a wide range of physiological activities. Despite extensive research, its precise biological role and mechanism of action remain unclear, leading some researchers to describe it as an "unresolved riddle" in neuroscience.

Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Molecular Formula: C35H48N10O13

Molecular Weight: 848.8 g/mol

CAS Number: 62568-57-4

  1. Sleep Regulation: While initially thought to be a potent sleep inducer, subsequent studies have shown inconsistent results regarding DSIP's direct effects on sleep. Some studies report improvements in sleep efficiency and reduced sleep latency, while others find minimal effects on sleep architecture.
  2. Neuroendocrine Modulation: DSIP has been shown to influence various hormonal systems, including reducing basal corticotropin levels and stimulating the secretion of luteinizing hormone, somatoliberin, and somatotropin.
  3. Stress Protection: Several studies have demonstrated DSIP's stress-protective and adaptive activities, including its ability to normalize brain metabolism in amphetamine-induced stereotypy models.
  4. Neuroprotection: DSIP has shown neuroprotective properties in animal models of global brain ischemia, improving locomotor functions and reducing lethality.
  5. Pain Management: Some clinical studies have reported DSIP's effectiveness in reducing chronic pain, particularly in patients with migraines and vasomotor headaches.

  1. Mechanism of Action: Further research is needed to elucidate the precise molecular mechanisms by which DSIP exerts its diverse effects across different physiological systems.
  2. DSIP-like Peptides: Investigation into the potential existence of DSIP-like peptides that may be responsible for the observed DSIP-like immunoreactivity and biological activity.
  3. Clinical Applications: More rigorous clinical trials are required to evaluate DSIP's potential therapeutic uses in sleep disorders, stress-related conditions, and pain management.
  4. Long-term Safety: Extended studies to assess the long-term effects and safety profile of DSIP administration in various patient populations.
  5. Receptor Identification: Research aimed at identifying and characterizing specific DSIP receptors, which have not yet been isolated.

  1. Schoenenberger, G.A., et al. (1977). Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proceedings of the National Academy of Sciences, 74(3), 1282-1286. [Online].
    Available: https://pubmed.ncbi.nlm.nih.gov/265573/
  2. Kovalzon, V.M., & Strekalova, T.V. (2006). Delta sleep‐inducing peptide (DSIP): a still unresolved riddle. Journal of Neurochemistry, 97(2), 303-309. [Online].
    Available: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2006.03693.x
  3. Schneider-Helmert, D., & Schoenenberger, G.A. (1983). Effects of DSIP in man. Pharmacology, 26(3), 121-130. [Online].
    Available: https://pubmed.ncbi.nlm.nih.gov/6346775/
  4. Tukhovskaya, E.A., et al. (2021). Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke. Biomolecules, 11(9), 1279. [Online].
    Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434407/
  5. Graf, M.V., & Kastin, A.J. (1986). Delta-sleep-inducing peptide (DSIP): an update. Peptides, 7(6), 1165-1187. [Online].
    Available: https://pubmed.ncbi.nlm.nih.gov/3550726/
DSIP represents an intriguing and complex neuropeptide with potential implications in various physiological processes. While its exact role remains unclear, ongoing research continues to explore its therapeutic potential in sleep disorders, stress management, and neuroprotection. As with all peptide therapies, it is important to approach DSIP with caution, and its potential benefits and risks require further scientific scrutiny.